Who discovered waldenstrom macroglobulinemia?

Last Update: May 30, 2022

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Jan Gösta Waldenström (17 April 1906 – 1 December 1996) was a Swedish doctor of internal medicine, who first described the disease which bears his name, Waldenström's macroglobulinemia.

When was Waldenstrom's macroglobulinemia discovered?

The gene had been discovered in 1993, while a molecule designed to shut it down had been lurking on lab benches since the late '90s. Treon led a clinical trial of the BTK inhibitor Imbruvica in 63 previously treated patients with Waldenstrom macroglobulinemia.

How rare is Waldenstrom's Macroglobulinemia?

Waldenstrom macroglobulinemia (WM) is rare, with an incidence rate of about 3 cases per million people per year in the United States. About 1,000 to 1,500 people are diagnosed with WM each year in the United States.

How did Waldenstrom get its name?

These abnormal cells produce excess amounts of IgM , a type of protein known as an immunoglobulin; the overproduction of this large protein is how the condition got its name ("macroglobulinemia").

Is WM hereditary?

Heredity. Inherited genes seem to play a role in at least some people who get WM. About 1 in 5 people with WM has a close relative with WM or with a related B-cell disease, such as MGUS or certain types of lymphoma or leukemia.

Waldenstrom macroglobulinemia - an Osmosis Preview

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Is Waldenstrom a form of leukemia?

Waldenstrom macroglobulinemia is considered a type of non-Hodgkin's lymphoma. It's sometimes called lymphoplasmacytic lymphoma.

How is Waldenstrom diagnosed?

Tests and procedures used to diagnose Waldenstrom macroglobulinemia include:
  1. Blood tests. Blood tests may reveal low numbers of healthy blood cells. ...
  2. Collecting a sample of bone marrow for testing. During a bone marrow biopsy, your doctor uses a needle to extract some of your bone marrow from your hipbone. ...
  3. Imaging tests.

Is Waldenstrom's a plasma cell disorder?

WM is commonly classified as a form of plasma cell dyscrasia, similar to other plasma cell dyscrasias that, for example, lead to multiple myeloma, WM is commonly preceded by two clinically asymptomatic but progressively more pre-malignant phases, IgM monoclonal gammopathy of undetermined significance (i.e. IgM MGUS) ...

What causes Waldenstrom macroglobulinemia?

What causes Waldenstrom macroglobulinemia (WM)? Doctors do not know what causes WM but believe it involves a gene mutation. Recent research has found that WM cells have a mutation (change) in a gene known as MYD88, which normally helps immune system cells signal each other and helps keep them alive.

Is Waldenstrom's fatal?

WM is a fairly indolent, chronic disease in most patients. The median survival has varied in studies, from 5 years to nearly 11 years. The main causes of death because of WM include disease progression, transformation to high-grade lymphoma or complications of therapy.

Is Waldenstrom curable?

Waldenstrom macroglobulinemia (WM) is generally not considered to be curable, but it is treatable. Many different medicines can help keep WM under control, often for long periods of time. Not everyone with WM needs treatment right away. In fact, some people are diagnosed with WM before they even have symptoms from it.

How many people in the world have Waldenstrom's macroglobulinemia?

Affected Populations

Waldenström macroglobulinemia is a very rare disorder affecting about 1 in 3.4 million American men and about half that number of American women. The incidence of WMG is estimated to be about 5 per 1,000,000 people over the age of 50. The median age at diagnosis is 67.

Can Waldenstrom's become multiple myeloma?

The cancer cells of Waldenstrom's are similar to those of two other types of cancer: multiple myeloma and non-Hodgkin lymphoma.

Can Waldenstrom be misdiagnosed?

Because Waldenström's is rare, it is often misdiagnosed. It important to be seen at – or consult with – a treatment center like ours that cares for many patients with this kind of cancer.

What is smoldering Waldenstrom's?

Smoldering Waldenström macroglobulinemia (also referred to as indolent or asymptomatic Waldenström macroglobulinemia) is defined as a serum IgM monoclonal protein level of 3 g/dL or higher and/or bone marrow lymphoplasmacytic infiltration of 10% or greater and no evidence of end-organ damage, such as anemia, ...

Can Waldenstrom's spread?

Because lymphatic tissue is found in so many parts of the body, Waldenstrom macroglobulinemia can start almost anywhere and may spread to almost any organ in the body. When people are first diagnosed with the disease, it has usually already spread to the blood and bone marrow.

Does Waldenstrom's metastasize?

Can Waldenstrom macroglobulinemia metastasize? Yes. WM affects lymphatic tissue, which is found in many parts of the body. By the time a person is diagnosed with the disease, it can already be found in the blood and bone marrow.

What is Waldenstrom's disease?

Waldenstrom macroglobulinemia (WM) is a type of non-Hodgkin lymphoma (NHL). The cancer cells make large amounts of an abnormal protein (called a macroglobulin). Another name for WM is lymphoplasmacytic lymphoma.

Is Waldenstrom's macroglobulinemia an autoimmune disease?

Waldenström macroglobulinemia represents a lymphoplasmacytic lymphoma with an indolent clinical course. The existing literature associates this hematologic malignancy with various autoimmune disorders. Notwithstanding, these autoimmune conditions have not been comprehensively characterized or systematized to date.

What are the symptoms of high IgM levels?

If the amount of IgM in your body becomes severely high, you may experience additional symptoms.
Some less common symptoms include:
  • bleeding from the gums or nose.
  • bruises.
  • skin lesions.
  • skin discoloration.
  • swollen glands.
  • heart problems.
  • kidney problems.
  • digestive symptoms.

How does a person get multiple myeloma?

What causes multiple myeloma? The exact cause of multiple myeloma is unknown. However, it starts with one abnormal plasma cell that rapidly multiplies in the bone marrow many more times than it should. The resulting cancerous myeloma cells don't have a normal life cycle.

How quickly does Waldenstrom's progress?

The cumulative probability of progression to symptomatic WM, amyloidosis, or lymphoma was 6% at 1 year, 39% at 3 years, 59% at 5 years, and 68% at 10 years. The major risk factors for progression were percentage of lymphoplasmacytic cells in the bone marrow, size of the serum M-spike, and the hemoglobin value.

Is Waldenstrom's painful?

If the M protein only thickens the blood in cooler parts of the body (like in the tip of the nose, ears, fingers, and toes), it is called a cryoglobulin. Cryoglobulins can cause pain or other problems in these areas if a person is exposed to cooler temperatures.