In pathology what is atherosclerosis?

Last Update: October 15, 2022

This is a question our experts keep getting from time to time. Now, we have got a complete detailed explanation and answer for everyone, who is interested!

Asked by: Dovie Wolf
Score: 4.9/5 (46 votes)

Atherosclerosis is a disease of the arterial wall that occurs at susceptible sites in the major conduit arteries. It is initiated by lipid retention, oxidation, and modification, which provoke chronic inflammation, ultimately causing thrombosis or stenosis.

What are the three stages of atherosclerosis?

It focuses on three basic stages of the disease processes: initiation of the fatty streak, transition of the fatty streak to an atheroma, and progression and destabilization of the lesions leading to plaque rupture and occlusive thrombosis.

What is the first step of atherosclerosis pathology?

Lipid retention is the first step in the pathogenesis of atherosclerosis which is followed by chronic inflammation at susceptible sites in the walls of the major arteries lead to fatty streaks, which then progress to fibroatheromas which are fibrous in nature (Table 1) [5,6].

What is atherosclerosis answer?

Atherosclerosis is a hardening and narrowing of your arteries. It can put blood flow at risk as your arteries become blocked. You might hear it called arteriosclerosis or atherosclerotic cardiovascular disease.

Can you live a long life with atherosclerosis?

Living healthy with atherosclerosis is possible with proper management, so take steps toward better heart health now. Atherosclerosis doesn't have to be a losing battle. In fact, the disease can be reversed through lifestyle changes, according to the American College of Cardiology.

Arteriosclerosis, Atherosclerosis & Arteriolosclerosis- pathology

42 related questions found

What are the 4 stages of atherosclerosis?

Atherosclerosis is the pathologic process by which cholesterol and calcium plaque accumulate within the arterial wall.
...
The working theory includes four steps:
  • Endothelial cell injury. ...
  • Lipoprotein deposition. ...
  • Inflammatory reaction. ...
  • Smooth muscle cell cap formation.

What are two of the hallmark signs of atherosclerosis?

If you have atherosclerosis in the arteries leading to your brain, you may have signs and symptoms such as sudden numbness or weakness in your arms or legs, difficulty speaking or slurred speech, temporary loss of vision in one eye, or drooping muscles in your face.

What are the 5 stages of atherosclerosis?

Atherogenesis can be divided into five key steps, which are 1) endothelial dysfunction, 2) formation of lipid layer or fatty streak within the intima, 3) migration of leukocytes and smooth muscle cells into the vessel wall, 4) foam cell formation and 5) degradation of extracellular matrix.

How fast does atherosclerosis progress?

Although atherosclerosis is believed to progress over many years, it has been increasingly noted to progress over few months to 2-3 years in few patients without traditional factors for accelerated atherosclerosis.


What is end stage atherosclerosis?

ESRD is characterized by an exceptionally high mortality rate, largely related to cardiovascular disease, including accelerated atherosclerosis and its complications. The accelerated atherosclerotic process in these patients is attributable, at least in part, to chronic inflammation.

Can atherosclerosis be fixed?

Lifestyle changes, such as eating a healthy diet and exercising, are the first treatment for atherosclerosis — and may be all that you need to treat your atherosclerosis. But sometimes, medication or surgical procedures may be needed.

Can you reverse the effects of atherosclerosis?

Medical treatment combined with lifestyle and dietary changes can be used to keep atherosclerosis from getting worse, but they aren't able to reverse the disease. Some medications may also be prescribed to increase your comfort, particularly if you're having chest or leg pain as a symptom.

What 3 foods cardiologists say to avoid?

Foods That Are Bad for Your Heart
  • Sugar, Salt, Fat. Over time, high amounts of salt, sugar, saturated fat, and refined carbs raise your risk for a heart attack or stroke. ...
  • Bacon. ...
  • Red Meat. ...
  • Soda. ...
  • Baked Goods. ...
  • Processed Meats. ...
  • White Rice, Bread, and Pasta. ...
  • Pizza.


How serious is atherosclerosis?

Over time, plaque hardens and narrows your arteries. This limits the flow of oxygen-rich blood to your organs and other parts of your body. Atherosclerosis can lead to serious problems, including heart attack, stroke, or even death.

Can atherosclerosis cause sudden death?

Coronary atherosclerosis is responsible for >50% of all cases of sudden death and for 90% of sudden coronary death.

What are the main causes of atherosclerosis?

Key points of atherosclerosis

Atherosclerosis is thickening or hardening of the arteries caused by a buildup of plaque in the inner lining of an artery. Risk factors may include high cholesterol and triglyceride levels, high blood pressure, smoking, diabetes, obesity, physical activity, and eating saturated fats.

Is Ed a symptom of atherosclerosis?

Erectile dysfunction is frequently a sign of atherosclerosis, a clogging or narrowing of the blood vessels that causes heart attacks. Erectile dysfunction usually comes 3 to 5 years before a heart attack, so after ED is diagnosed, there is time to treat atherosclerosis and prevent a heart attack.


What is the difference between arteriosclerosis and atherosclerosis?

Arteriosclerosis is a broader term for the condition in which the arteries narrow and harden, leading to poor circulation of blood throughout the body. Atherosclerosis is a specific kind of arteriosclerosis, but these terms are often used interchangeably.

What does a blocked artery feel like?

The symptoms of an artery blockage include chest pain and tightness, and shortness of breath. Imagine driving through a tunnel. On Monday, you encounter a pile of rubble. There is a narrow gap, big enough to drive through.

What are the warning signs of clogged arteries?

In addition to developing feet and leg issues, clogged arteries can cause you to experience dizzy, weak feelings, and heart palpitations. You may also sweat, feel nauseated, or have difficulty breathing.

Can an ECG detect a blocked artery?

An ECG Can Recognize the Signs of Blocked Arteries.

Unfortunately, the accuracy of diagnosing blocked arteries further from the heart when using an ECG decrease, so your cardiologist may recommend an ultrasound, which is a non-invasive test, like a carotid ultrasound, to check for blockages in the extremities or neck.


What is the first stage in atherosclerosis?

The oxidation of low density lipoprotein (LDL) to Ox-LDL indicates the first step of atherosclerosis in cardiovascular diseases. Malondialdehyde factor shows the level of lipoperoxidation and is a sign of increased oxidative pressure and cardiovascular diseases.

How does atherosclerosis progress?

Atherosclerosis develops progressively through continuous evolution of arterial wall lesions centered on the accumulation of cholesterol-rich lipids and the accompanying inflammatory response. These changes have been described in the histopathology of human plaques and the plaques of experimental animals.

What is the number 1 vegetable to avoid?

Strawberries top the list, followed by spinach. (The full 2019 Dirty Dozen list, ranked from most contaminated to least, include strawberries, spinach, kale, nectarines, apples, grapes, peaches, cherries, pears, tomatoes, celery and potatoes.)

What is the number 1 healthiest food in the world?

So, having scoured the full list of applicants, we have crowned kale as the number 1 healthiest food out there. Kale has the widest range of benefits, with the fewest drawbacks when stacked up against its competitors.