Are theophylline and aminophylline the same?

Last Update: May 30, 2022

This is a question our experts keep getting from time to time. Now, we have got the complete detailed explanation and answer for everyone, who is interested!

Asked by: Prof. Abigayle Bernier DDS
Score: 4.8/5 (13 votes)

Aminophylline is the ethylenediamine salt of theophylline. Theophylline stimulates the CNS, skeletal muscles, and cardiac muscle. It relaxes certain smooth muscles in the bronchi, produces diuresis, and causes an increase in gastric secretion. Aminophylline is the ethylenediamine salt of theophylline.

What is the generic name for aminophylline?

Theophylline is available under the following different brand names: Theo 24, Theochron, Elixophyllin, aminophylline, and Uniphyl.

Is there a substitute for theophylline?

Abstract: Doxofylline, which differs from theophylline in containing the dioxalane group at position 7, has comparable efficacy to theophylline in the treatment of respiratory diseases, but with an improved tolerability profile and a favorable risk-to-benefit ratio.

What is the brand name of theophylline?

Theophylline is marketed under several brand names such as Uniphyl and Theochron, and it is indicated mainly for asthma, bronchospasm, and COPD.

What can I use instead of aminophylline?

Adenosine and dobutamine can be used as alternatives to regadenoson and dipyridamole to decrease or eliminate the use of aminophylline. Alternatives to aminophylline include theophylline and caffeine.

Pharmacology - Bronchodilators - Respiratory Drugs nursing RN PN NCLEX

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What should I check before giving aminophylline?

If you do not know whether your medication is an extended-release formulation, ask your pharmacist. Call your doctor right away if you experience nausea, vomiting, insomnia, restlessness, seizures, increased heart rate, or a headache. These could be signs of too much aminophylline in your blood.

When do you give aminophylline?

Aminophylline Injection is indicated for relief of bronchospasm associated with asthma and in chronic obstructive pulmonary disease. Maintenance therapy can be administered via larger volume infusion solutions, rate-regulated to deliver the required amount of drug each hour.

Why is theophylline no longer used?

Oral theophylline has been used as a bronchodilator to treat chronic obstructive pulmonary disease (COPD) for decades, but it has fallen out of favor due to the side effects that come with the higher doses that are required to achieve any beneficial effect, as well as the advancement of improved drug treatment.

What foods contain theophylline?

Theophylline is found in black tea and to a lesser extent in green coffee, cocoa cotyledon and dried mate. Theophylline is synthesized on an industrial scale and is used principally in pharmaceutical preparations.

What is the pH of theophylline?

While salts of theophylline may be formed with a base at high pH, theophylline is only slightly ionized at physiological pH (pKa = 8.8).

Is theophylline used anymore?

While theophylline has been used in the treatment of asthma since 1922, it has since fallen in and out of favor with doctors and, today, is not as commonly used as it once was.

Is theophylline still used for COPD?

Theophylline has been used in the treatment of chronic obstructive airway diseases, including chronic obstructive pulmonary disease (COPD), for more than 70 years. It is still widely prescribed worldwide, because it is inexpensive.

Is theophylline discontinued?

Reason for the Shortage

Major has discontinued theophylline extended-release tablets. Teva has had theophylline extended-release tablets temporarily unavailable for several years. Theophylline 24-hour extended-release presentations are available from Mylan, Rhodes, and Endo Pharmaceuticals.

Can you drink coffee with theophylline?

theophylline caffeine

Avoid drinks or foods that contain caffeine, such as coffee, tea, cola, and chocolate. You may need a dose adjustment or special test if you use both medications.

What is oral theophylline?

Theophylline is used to treat lung diseases such as asthma and COPD (bronchitis, emphysema). It must be used regularly to prevent wheezing and shortness of breath. This medication belongs to a class of drugs known as xanthines.

Do you need a prescription for theophylline?

Theophylline is a prescription drug. It's available as an oral solution, an extended-release tablet, and an extended-release capsule. It's also available in an intravenous (IV) form, which is only given by a healthcare provider. The theophylline tablet is only available as a generic drug.

Does green tea has theophylline?

Green tea extract contains polyphenols. These include the most active type, epigallocatechin gallate. Green tea and oolong tea have the highest levels of polyphenols. ... Other significant parts of tea include caffeine, theobromine, and theophylline.

Does coffee contain methylxanthine?

Methylxanthines, namely caffeine, theobromine and theophylline are found in several beverages and food products such as coffee, cocoa, tea and cola drinks. These substances can provide benefits to humans but also prove harmful mainly when consumed in high amounts.

What is a normal theophylline level?

Therapeutic serum levels of theophylline are between 10 to 20 mcg/ml. Most adults achieve these concentrations with daily slow-release oral theophylline preparations, 200-400 mg (approximately 10 mg/Kg) twice a day.

How long should I take theophylline?

It usually is taken every 6, 8, 12, or 24 hours. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take theophylline exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

What are indications for theophylline?

Theophylline is indicated for the treatment of the symptoms and reversible airflow obstruction associated with chronic asthma and other chronic lung diseases, e.g., emphysema and chronic bronchitis.

Can you overdose on theophylline?

Data from this cohort study indicate that theophylline is an extremely toxic drug that, in overdose, may cause harm or death. Three distinct patterns of intoxication exist, namely, acute intoxication, chronic overmedication, and acute-on-therapeutic intoxication.

Can aminophylline be given orally?

Aminophylline Oral Liquid is available as a solution intended for oral administration, containing 105 mg of anhydrous Aminophylline per 5 mL (equivalent to 90 mg of anhydrous theophylline per 5 mL).

What are aminophylline side effects?

increased or rapid heart rate. irregular heartbeat. seizures. skin rash.

When should I stop aminophylline infusion?

The aim is to reduce the infusion over a 10-12 hour period of time once stable. It is recommended that dose reduction begin in the morning, aiming to stop the infusion by mid to late afternoon.